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| Slide Lecture Programs |
| 2006 Core Curriculum |
| Contemporary Management of Myocardial Ischemia |
May 17, 2006
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| V: |
New Therapeutic Options for Chronic Stable Angina |
Slide 76 |
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Potential cardioprotective benefits of exercise
- Physical conditioning increases exercise duration and work capacity, prolonging time to angina.
- Exercise is associated with cardioprotective benefits beyond improvement in aerobic capacity alone.
- Molecular effects: Functional effects:
| - ↑eNOS expression and activation | - Vasculature | | - ↑NAD(P)H expression and activity | ↑Endothelial function | | - ↑AT1 receptor expression | ↑Peripheral tone | | - ↑SOD expression | ↑Plasma volume | | - Other effects | ↓BP | | ↓Intimal thickness | - Myocardium | | ↓P selectin | ↑Vagal tone | | ↓VCAM-1 | ↓HR | | ↓MCP-1 | ↓O2 demand | | ↓Ca2+ in VSMC | ↑Preconditioning | | | - Thrombosis | | | ↑Fibrinolytic balance |
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