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| Slide Lecture Programs |
| 2006 Core Curriculum |
| Contemporary Management of Myocardial Ischemia |
May 17, 2006
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| V: |
New Therapeutic Options for Chronic Stable Angina |
Slide 74 |
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Ranolazine: No apparent proarrhythmic characteristics
- There appears to be no evidence that ranolazine has any effect on either the trigger or substrate of torsade de pointes.
- Ranolazine was not shown to cause EADs over concentration range 1-300 µM (wide range of models) and it suppressed EADs induced by proarrhythmic agents such as sotalol (eg, studies in Purkinje fibers, cardiomyocytes, whole rabbit hearts).
- Ranolazine was found to have no effect on QT dispersion in humans at 500-1500 mg bid (MARISA trial).
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