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| Slide Lecture Programs |
| 2006 Core Curriculum |
| Contemporary Management of Myocardial Ischemia |
May 17, 2006
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| V: |
New Therapeutic Options for Chronic Stable Angina |
Slide 73 |
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Overview of torsade de pointes
- Contrary to dogma, QT prolongation may not be a good predictor of torsade de pointes. This arrhythmia requires both early afterdepolarizations (EADs) and spatial dispersion of repolarization across the left ventricular wall (ie, transmural heterogeneity in prolongation of the action potential).
- EADs provide the trigger, and increased dispersion of ventricular repolarization the substrate, for development of torsade de pointes.
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