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| Slide Lecture Programs |
| 2006 Core Curriculum |
| Contemporary Management of Myocardial Ischemia |
May 17, 2006
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| V: |
New Therapeutic Options for Chronic Stable Angina |
Slide 72 |
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Late INa effect mitigates IKr effect
- In canine left ventricular myocardial cells, ranolazine, at concentrations comparable to those achieved in humans with oral dosing, inhibits the inward potassium rectifier current (IKr) and the late sodium current.
- IKr inhibition increases and late INa inhibition shortens the QT interval. The net effect at doses used clinically is a modest increase in the QT interval
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