Vascular Biology in Clinical Practice © Vol. 4, No. 5
• The potential role of beta-blockade in blunting the progression of atherosclerosis
This monograph, The potential role of beta-blockade in blunting the progression of atherosclerosis
, is offered as part of a series of continuing medical education programs from the University of Florida College of Medicine. Co-editors are Carl J. Pepine, MD, University of Florida College of Medicine, William W. Parmley, MD, University of California, San Francisco.
This monograph discusses the therapeutic mechanisms of ß-blockers, notably the latest clinical studies that have demonstrated antiatherosclerotic effects of ß-blockade in humans. Compelling evidence has established the benefit of ß-blockade in reducing mortality and morbidity in patients with hypertension, coronary artery disease, and heart failure. The two studies discussed in this monograph, with the acronyms of BCAPS and ELVA, have demonstrated a regression in carotid atherosclerosis with ß-blockade. The results suggest the importance of initiating ß-blockade early in the course of atherosclerotic disease as part of a management strategy to prevent the progression of hypertension to heart failure in older patients.