Vascular Biology in Clinical Practice © Vol. 2, No. 2
• RAS, lipids, and inflammation: New insights for therapeutic intervention
This monograph RAS, lipids, and inflammation: New insights for therapeutic intervention is offered as part of a series of continuing medical education programs from the University of Florida College of Medicine.
Is inflammation a response to endothelial injury or a primary cause of atherosclerotic disease? The evidence presented in this monograph, implicating proinflammatory cytokines as a major link between hypercholesterolemia, oxidative stress, and plaque stability, argues for the latter view. In addition, recent data suggest that angiotensin II may act as a proinflammatory stimulus. This finding helps explain how inhibition of vascular ACE reduces risk of acute ischemic events.