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Data alert

HOPE-TOO: Extended use of ACEI reduces CV risk and new diabetes, independent of baseline risk

Results from large clinical trials provide evidence that angiotensin-converting enzyme inhibitors (ACEIs) are effective in the treatment of cardiovascular (CV) disease. The Heart Outcomes Prevention Evaluation (HOPE) trial was stopped early (at 4.5 years) when the ACEI ramipril clearly provided benefit in reducing the risk of CV death, myocardial infarction (MI), and stroke in high-risk patients ages >55 years.1

More recently, the European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease (EUROPA) assessed the possible vascular and antiatherosclerotic effect of the ACEI perindopril 8 mg in a low-risk population (N = 12,218) of patients ages >18 years with stable CAD but without HF. At 4.2- years, ACEI treatment showed a 20% relative risk reduction in primary outcome (mortality, MI, cardiac arrest) (P = 0.0003).2

HOPE-TOO (HOPE-The Ongoing Outcomes), a 2.6-year extension study of HOPE, evaluated whether the benefits of ACEIs observed in the main HOPE trial are sustained with a longer period of observation and extend to all patients with CV disease.3




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Extension studies show sustained benefits with ACEI

Download VBWG05-RAAS-Data-Alert.ppt (6 slides - 0.1MB)

Extension studies show sustained benefits with ACEI HOPE-TOO: Study disposition HOPE-TOO: Baseline characteristics in extended follow-up HOPE-TOO: Primary outcome (CV death, MI, stroke) HOPE-TOO: Additional risk reduction in major CV events and new-onset diabetes Benefit of treatment with ACEI

For additional information on this study

References are listed at the end of the Data Alert.

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Data and Commentary:The HOPE Study

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