Data alert

Decrease in PAI-1 antigen is greater with ACE inhibition

Plasminogen activator inhibitor-1 (PAI-1) is a known risk factor for cardiovascular (CV) disease and myocardial infarction (MI). It is reduced by treatment with angiotensin-converting enzyme (ACE) inhibitors to a significantly greater extent than by treatment with angiotensin type 1 receptor antagonists. This effect is not only sustained, but actually increased over a 6-week time course.1

References are listed at the end of the Data Alert.

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