Data alert

SECURE: ACE inhibition retards the progression of atherosclerosis

Final results of the Study to Evaluate Carotid Ultrasound changes with Ramipril and vitamin E (SECURE) have been published and confirm that treatment with ramipril 10 mg slows the progression of atherosclerosis, while treatment with vitamin E has no apparent effect. The findings in SECURE, a substudy of the Heart Outcomes Prevention Evaluation (HOPE) study, parallel the results of the main study. HOPE showed that ramipril significantly reduced MI, stroke, and death, while vitamin E had no significant effect on clinical outcomes. HOPE and SECURE together demonstrate that ramipril reduces atherosclerosis progression and prevents major vascular events.


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