Core Curriculum

• Leading the Way in Cardiovascular Regenerative Medicine

Leading the Way in Cardiovascular Regenerative Medicine

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Leading the Way in Cardiovascular Regenerative Medicine CV disease: US prevalence New paradigm for CV disease Cell therapy CV disease targets for cell therapy clinical trials Some examples of CV disease targets in cell therapy trials in the US Cell transplantation for cardiac repair and/or inadequate blood supply: Rationale Damaged myocardium repair: New paradigm Why use adult stem cells? Role of the cell in cardiac regeneration therapy Cell-mediated CV repair Stem-cell homing: Chemoattractive hypothesis Possible routes for cell therapy to the heart

Endothelial Progenitor Cells (EPCs)

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Endothelial Progenitor Cells (EPCs) EPCs in CV diseases Circulating EPCs aid in cardiac repair EPC physiology EPC number has prognostic importance Association between CV risk factors and EPC colony counts Mobilization of EPCs after myocardial infarction VEGF levels correlate with increase in EPCs EPC activity and coronary collaterals Decrease in EPCs associated with CV disease

Bone Marrow Stem Cells in Cardiac Repair

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Bone Marrow Stem Cells in Cardiac Repair Stem cells in cardiac repair: Proposed mechanisms of action Bone marrow cells promote myocardial regeneration: Postulated mechanism Cardiac stem cells are derived, in part, from bone marrow Communication between heart and bone marrow signals in repair BMCs regenerate infarcted myocardium in mice BMCs reduce perfusion defect in ischemic pig hearts BMCs enhance collaterals to infarct region BMC therapy increases angiogenesis in ischemic pig hearts Infarcted myocardium repair via autologous intracoronary mononuclear BMC transplantation BMCs minimize infarcted myocardium region Assessment of intracoronary cell therapy in AMI Effects of intracoronary cell therapy on LVEF Autologous CD34+ cells for intractable angina Decrease in angina frequency with CD34+ cell therapy

Skeletal Myoblast Cells

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Skeletal Myoblast Cells Skeletal myoblasts Skeletal myoblasts Skeletal myoblast transplantation in post-MI HF patients Autologous skeletal myoblast injection for ischemic cardiomyopathy trial (MAGIC)

Cell Therapy in CV Disease: Newest Evidence

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Cell Therapy in CV Disease:Newest Evidence Induction of pluripotent stem cells from human fibroblasts Evidence for successful reprogramming of human fibroblasts* Effects of composite transcription factor modulation of human fibroblasts: Conclusions

Cell Therapy in CV Disease: Future Directions

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Cell Therapy in CV Disease:Future Directions Cardiac renewal: Is the goal in sight? Stem cell therapy: More questions than answers? CCTRN: Addressing gaps in the knowledge base CCTRN: Goal and initial phase I/II clinical trials CCTRN: Timeline of trials Summary
VBWG_CT.pdf (1.8MB)VBWG_CT.pdf (1.8MB)
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